Monomethyl phthalate → HCID 67050138, compound

HRID 1875845Notes

Reaction equation

HRID 1875845 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12](CC3C=C(C=CC=3)C(O)=O)[C:11]3[CH:23]=[C:24]([F:28])[C:25]([F:27])=[CH:26][C:10]=3[N:9]=2)=[C:4](OCC2CCCC2)[CH:3]=1.FC1C=C(N)C(N)=CC=1F.[CH3:46][O:47][C:48](=[O:58])C1C(=CC=CC=1)C(O)=O>>[CH3:46][O:47][C:48](=[O:58])[C:4]1[CH:3]=[CH:2][CH:7]=[CH:6][C:5]=1[C:8]1[NH:9][C:10]2[CH:26]=[C:25]([F:27])[C:24]([F:28])=[CH:23][C:11]=2[N:12]=1

Participants

4

Reactant 3

HCID 20392Monomethyl phthalateHCID 27367551,2-Diamino-4,5-difluorobenzeneHCID 582092763-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-benzoic acid

Product 1

HCID 67050138HCID 67050138, compound

Procedure

The title compound was prepared in analogy to Example 19, intermediate c, from 4,5-difluoro-benzene-1,2-diamine (CAS Reg. No. 76179-40-3) and phthalic acid monomethyl ester (CAS Reg. No. 4376-18-5). Off-white powder (12%). MS (Turbo Spray): m/z=289.0 (M+H).

Sources & evidence

ORD record
ord-ad6e838e747b4f6b8f3c0c903389dda7
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

Loading…