(Iodomethyl)cyclopentane → HCID 67050093, compound

HRID 1875846Notes

Reaction equation

HRID 1875846 reaction equation
[F:1][C:2]1[C:27]([F:28])=[CH:26][C:5]2[N:6]([CH2:16][C:17]3[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][C:18]=3[F:25])[C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[OH:15])=[N:8][C:4]=2[CH:3]=1.I[CH2:30][CH:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1>>[CH:31]1([CH2:30][O:15][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:7]2[N:6]([CH2:16][C:17]3[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][C:18]=3[F:25])[C:5]3[CH:26]=[C:27]([F:28])[C:2]([F:1])=[CH:3][C:4]=3[N:8]=2)[CH2:35][CH2:34][CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 2762531(Iodomethyl)cyclopentaneHCID 136378498HCID 136378498, compound

Product 1

HCID 67050093HCID 67050093, compound

Procedure

The title compound was prepared in analogy to Example 5, intermediate a, from 4-[5,6-difluoro-2-(2-hydroxy-phenyl)-benzoimidazol-1-ylmethyl]-3-fluoro-benzonitrile and iodomethyl-cyclopentane (CAS Reg. No. 27935-87-1). Off-white solid (51%). MS (Turbo Spray): m/z=462.2 (M+H).

Sources & evidence

ORD record
ord-be9551f2e2de4b29916ad97f906cef5c
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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