(Iodomethyl)cyclopentane → 4-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-benzoimidazol-1-ylmethyl]-3-fluoro-benzonitrile

HRID 1875848Notes

Reaction equation

HRID 1875848 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][C:15]=3[F:22])[C:11]3[CH:23]=[CH:24][CH:25]=[CH:26][C:10]=3[N:9]=2)=[C:4]([OH:27])[CH:3]=1.I[CH2:29][CH:30]1[CH2:34][CH2:33][CH2:32][CH2:31]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([CH2:13][C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][C:15]=3[F:22])[C:11]3[CH:23]=[CH:24][CH:25]=[CH:26][C:10]=3[N:9]=2)=[C:4]([O:27][CH2:29][CH:30]2[CH2:34][CH2:33][CH2:32][CH2:31]2)[CH:3]=1

Participants

3

Reactant 2

HCID 2762531(Iodomethyl)cyclopentaneHCID 1363784754-[2-(4-Chloro-2-hydroxy-phenyl)-benzoimidazol-1-ylmethyl]-3-fluoro-benzonitrile

Product 1

HCID 670500034-[2-(4-Chloro-2-cyclopentylmethoxy-phenyl)-benzoimidazol-1-ylmethyl]-3-fluoro-benzonitrile

Procedure

The title compound was prepared in analogy to Example 5, intermediate a, from 4-[2-(4-chloro-2-hydroxy-phenyl)-benzoimidazol-1-ylmethyl]-3-fluoro-benzonitrile and iodomethyl-cyclopentane (CAS Reg. No. 27935-87-1). Light yellow sticky solid (35%). MS (Turbo Spray): m/z=460.2 (M+H).

Sources & evidence

ORD record
ord-f00aa80304144273bbefc49e5fe37a99
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

Loading…