Hydrazine hydrate (1:1) → HCID 67321169, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(methylthio)-1H-pyrazole-3-carboxylate (6) (300 mg, 0.68 mmol) in EtOH (5 mL) was added hydrazine monohydrate (1 mL). The reaction mixture was refluxed for 2 h at 90° C. Reaction mixture was diluted with EtOAc and washed with saturated NaCl. The organic layer was dried over anhydrous MgSO4, filtered, and concentrated in vacuo to obtain 200 mg (70%) of the title compound as a white solid. The obtained compound was used for the next step without further purification.

Provenance & Evidence