反应详情

温度

50 °C

To 6-fluoro-1H-indazol-3-amine (0.32 g, 2.1 mmol) in dichloromethane (15 mL) was added 1,1′-thiocarbonyldipyridin-2(1H)-one (0.53 g, 2.30 mmol). The reaction was stirred at 50° C. for 3 hours. The reaction was cooled to room temperature and the crude product was purified by column chromatography (25% ethyl acetate/hexanes) to afford 6-fluoro-3-isothiocyanato-1H-indazole (0.30 g, 1.53 mmol, 73.0% yield) as a light yellow powder. 1H NMR (500 MHz, DMSO-D6) δ ppm 13.39 (s, 1H), 7.78 (dd, J=8.85, 4.88 Hz, 1H), 7.41 (dd, J=9.31, 1.68 Hz, 1H), 7.14 (td, J=9.16, 1.83 Hz, 1H). MS (LC/MS) R.T.=3.69; [M+H]+=194.07.

1. temperatureThe reaction was cooled to room temperature
2. customthe crude product was purified by column chromatography (25% ethyl acetate/hexanes)