Ammonium Hydroxide → 6-(Methoxymethyl)-4-pyrimidinamine

HRID 1875910ノート

反応式

HRID 1875910 の反応式
Cl[C:2]1[CH:7]=[C:6]([CH2:8][O:9][CH3:10])[N:5]=[CH:4][N:3]=1.[OH-].[NH4+:12]>>[CH3:10][O:9][CH2:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH2:12])[CH:7]=1

参加物

3

反応物 2

HCID 14923Ammonium HydroxideHCID 143061714-Chloro-6-(methoxymethyl)pyrimidine

生成物 1

HCID 211376446-(Methoxymethyl)-4-pyrimidinamine収率 48%

実験手順

A mixture of 4-chloro-6-(methoxymethyl)pyrimidine (1.2 g, 7.57 mmol) and ammonium hydroxide (20 ml) was heated in a sealed tube for 3 hours. The mixture was cooled to ambient temperature and concentrated. The residue was triturated with ether to afford 6-(methoxymethyl)pyrimidin-4-amine (0.50 g, 3.59 mmol, 48% yield) as a pale yellow solid. 1H NMR (400 MHz, CDCl3) δ ppm 8.47 (1H, s), 6.55 (1H, s), 5.12 (2H, br. s.), 4.38 (2H, s), 3.45 (3H, s). MS (LC/MS) R.T.=0.42; [M+H]+=140.20.

後処理

  1. temperaturewas heated in a sealed tube for 3 hours
  2. concentrationconcentrated
  3. customThe residue was triturated with ether

出典と根拠

ORDレコード
ord-e6ee90cf14394f2d975b9858b047d98c
出典データセット
uspto-grants-2012_11
特許番号
US08309577B2

反応ノート

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