L-Methionine → Carbonimidodithioic acid, N-[6-(2-pyrazinyl)-4-pyrimidinyl]-, dimethyl ester

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Reaction Steps

To a solution of 6-(pyrazin-2-yl)pyrimidin-4-amine (0.2 g, 1.155 mmol) in DMF was added NaOH (0.115 mL, 2.310 mmol), CS2 (0.174 mL, 2.89 mmol), NaOH (0.115 mL, 2.310 mmol) and Met (0.181 mL, 2.89 mmol) at 15 min intervals. Stirring was continued for 1.5 h and the mixture was poured into water. The orange solid was separated, washed with water, dried to give a bright yellow solid (0.14 g, 0.505 mmol, 44%). MS (LC/MS) R.T.=3.19; [M+H]+=278.19.

Provenance & Evidence