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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 187607Generated: October 28, 2026

Acetic Acid → 1-(3-Carbamoyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)thiophen-2-yl)urea

https://huagongshe.com/reaction/187607

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
Reactant1,2-DimethoxyethaneHCID 8071—
ReactantTrimethyl orthoformateHCID 9005—
ReactantDimethylacetamideHCID 31374—
Reactant1-MethylpiperazineHCID 53167—
ReactantIsocyanateHCID 105034—
ReactantCyano-borohydrideHCID 498716—
Reactant2-[(Aminocarbonyl)amino]-5-[4-formylphenyl]thiophene-3-carboxamideHCID 21914326—
Product1-(3-Carbamoyl-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)thiophen-2-yl)ureaHCID 21914398—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (6/10)
ORD IDord-927be25d0c644a36a96cf54abcc8c660
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (6/10)