HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → (2-Chloro-quinazolin-4-yl)-(2,3-dimethoxy-phenyl)-methyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 2-Chloro-N-(2,3-dimethoxyphenyl)quinazolin-4-amine | HCID 57938809 | — |
| Product | (2-Chloro-quinazolin-4-yl)-(2,3-dimethoxy-phenyl)-methyl-amine | HCID 11244386 | — |
Reaction Steps
The title compound was prepared from (2-chloro-quinazolin-4-yl)-(2,3-dimethoxy-phenyl)-amine and methyl iodide by a procedure similar to Example 36 (71% yield). 1H NMR (CDCl3): 7.74 (d, J=8.4 Hz, 1H), 7.53-7.59 (m, 1H), 7.12 (t, J=8.4 Hz, 1H), 6.94-7.01 (m, 3H), 6.87 (dd, J=8.1 and 1.5 Hz, 1H), 3.89 (s, 3H), 3.56 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309562B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-dae0f32706e94b6f838b3c45d2d0736e |
| Source note | uspto-grants-2012_11 |