Methyl iodide → 2-chloro-N-(2,5-dimethoxyphenyl)-N-methylquinazolin-4-amine

HRID 1876089Notes

Reaction equation

HRID 1876089 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([NH:12][C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[O:21][CH3:22])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:23]I>>[Cl:1][C:2]1[N:11]=[C:10]([N:12]([C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[O:21][CH3:22])[CH3:23])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 226927372-Chloro-N-(2,5-dimethoxyphenyl)quinazolin-4-amine

Product 1

HCID 112559672-chloro-N-(2,5-dimethoxyphenyl)-N-methylquinazolin-4-amine

Procedure

The title compound was prepared from (2-chloro-quinazolin-4-yl)-(2,5-dimethoxy-phenyl)-amine and methyl iodide by a procedure similar to Example 36 (78% yield). 1H NMR (CDCl3): 7.72-7.75 (m, 1H), 7.56 (ddd, J=8.4, 5.7 and 2.1 Hz, 1H), 6.98-7.00 (m, 2H), 6.92-6.92 (m, 2H), 6.78-6.79 (m, 1H), 3.75 (s, 3H), 3,58 (s, 3H), 3.56 (s, 3H).

Sources & evidence

ORD record
ord-ce2eb36a6fb74009835bd00e1eddfd49
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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