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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1876112Generated: October 30, 2026

4-Ethylaniline → N-(4-Ethylphenyl)-2-methylquinazolin-4-amine

https://huagongshe.com/reaction/1876112

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-EthylanilineHCID 11504—
Reactant4-Chloro-2-methylquinazolineHCID 2785421—
ProductN-(4-Ethylphenyl)-2-methylquinazolin-4-amineHCID 42625917—

Reaction Steps

The title compound was prepared from 4-chloro-2-methyl-quinazoline (100 mg, 0.56 mmol), 4-ethyl-phenylamine (0.07 ml, 0.56 mmol) by a procedure similar to Example 78. 1H NMR (CDCl3): 7.85-7.78 (m, 2H), 7.76-7.71 (m, 3H)), 7.49 (t, J=7.5 Hz, 1H), 7.36 (brs, 1H), 7.24 (s, 2H), 2.70-2.69 (m, 5H), 1.26 (t, J=7.5 Hz, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08309562B2
Source datasetuspto-grants-2012_11
ORD IDord-1fcdb7136d5f4579b1a6782331facebb
Source noteuspto-grants-2012_11