Methyl iodide → 4-Quinazolinamine, N-(4-ethylphenyl)-N,2-dimethyl-

HRID 1876118Notes

Reaction equation

HRID 1876118 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=[C:12]([CH3:20])[N:11]=2)=[CH:5][CH:4]=1)[CH3:2].[CH3:21]I>>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([N:9]([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=[C:12]([CH3:20])[N:11]=2)[CH3:21])=[CH:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 42625917N-(4-Ethylphenyl)-2-methylquinazolin-4-amine

Product 1

HCID 114828124-Quinazolinamine, N-(4-ethylphenyl)-N,2-dimethyl-

Procedure

The title compound was prepared from (4-ethyl-phenyl)-(2-methyl-quinazolin-4-yl)-amine (122 mg, 0.46 mmol) and methyl iodide (0.2 ml, 3.25 mmol) by a procedure similar to Example 36. 1H NMR (CDCl3): 7.74 (d, J=8.1 Hz, 1H), 7.54-7.49 (m, 1H), 7.19 (d, J=8.4 Hz, 2H), 7.09-6.92 (m, 4H), 3.61 (s, 3H), 2.73-2.63 (m, 5H), 1.26 (d, J=7.5 Hz, 3H).

Sources & evidence

ORD record
ord-e534a74da2f24561bd7044bd3eaac384
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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