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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1876127Generated: November 1, 2026

4-Ethoxyaniline → 4-Quinazolinamine, N-(4-ethoxyphenyl)-2-methyl-

https://huagongshe.com/reaction/1876127

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-EthoxyanilineHCID 9076—
Reactant4-Chloro-2-methylquinazolineHCID 2785421—
Product4-Quinazolinamine, N-(4-ethoxyphenyl)-2-methyl-HCID 4415039—

Reaction Steps

The title compound was prepared from 4-chloro-2-methylquinazoline and 4-ethoxyaniline by a procedure similar to Example 28 (93%). 1H NMR (CDCl3): 7.83 (m, 1H), 7.81 (m, 1H), 7.42 (m, 1H), 7.65-7.71 (m, 2H), 7.46 (ddd, J=8.4, 6.9, 1.5, 1H), 7.37 (s, broad, 1H), 6.92-6.97 (m, 2H), 4.06 (q, J=6.9, 2H), 2.68 (s, 3H), 1.43 (t, J=6.9, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08309562B2
Source datasetuspto-grants-2012_11
ORD IDord-346a0c24e1104a5c8b8a51a67d8e0d88
Source noteuspto-grants-2012_11