N-Methyl-4-anisidine → HCID 11163523, compound

HRID 1876130Notes

Reaction equation

HRID 1876130 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:3]=1.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([NH:25][CH3:26])=[CH:21][CH:20]=1>>[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[C:4]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:3]=2)[CH3:26])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 22250N-Methyl-4-anisidineHCID 3477840Ethyl 4-chloroquinazoline-2-carboxylate

Product 1

HCID 11163523HCID 11163523, compound

Procedure

The title compound was prepared from ethyl 4-chloroquinazoline-2-carboxylate and (4-methoxy-phenyl)-methylamine by using the procedure described for Example 1b. 1H NMR (CDCl3): 7.98-8.02 (m, 1H), 7.61 (ddd, J=1H, 8.1, 6.9, 1.5), 7.08-7.17 (m, 3H), 7.01-7.05 (m, 1H), 6.91-6.96 (m, 2H), 4.56 (q, J=2H, 7.2), 3.84 (s, 3H), 3.71 (s, 3H), 1.50 (t, J=2H, 7.2).

Sources & evidence

ORD record
ord-e5bc22d5cbc54c0fa63231d33a41e5c7
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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