Ethanolamine → HCID 59242100, compound

Participants

Reaction Steps

A solution of (2-chloro-6-methyl-quinazolin-4-yl)-(4-methoxyphenyl)-methyl-amine (50.3 mg, 0.16 mmol) in ethanolamine (1.5 mL) was heated to 140° C. in the microwave for 20 min. The reaction was then concentrated onto SiO2 and purified by gradient MPLC (SiO2, 0-100%, EtOAc/hexanes, 20 min). 19.1 mg (35%) of the title compound was isolated: 1H NMR (DMSO-d6) δ 7.33 (d, 1 H), 7.21 (dd, 1 H), 7.04-7.10 (m, 2H), 6.86-6.92 (m, 2H), 6.57-6.62 (m, 1H), 5.44 (br s, 1H), 3.82-3.94 (m, 2H), 3.83 (s, 3H), 3.62-3.67 (m, 2H), 3.48 (s, 3H), 2.01 (s, 3H). HRMS (ES) calcd for C19H23N4O2 [(M+H)] 339.1816, found 339.1854.

Provenance & Evidence