4-Amino-1-butanol → 4-{4-[(4-Methoxy-phenyl)-methyl-amino]-quinazolin-2-ylamino}-butan-1-ol

Participants

Reaction Steps

The title compound was prepared from (2-chloro-quinazolin-4-yl)-(4-methoxy-phenyl)-methyl-amine hydrochloride (81 mg, 0.24 mmol) and 4-amino-butan-1-ol (69 μL, 0.75 mmol) by a procedure similar to Example 180, yielding a pale yellow oil (55 mg; 65%). 1H NMR (CDCl3) δ 7.48 (m, 1H), 7.38 (m, 1H), 7.12 (m, 2H), 6.91 (m, 2H), 6.81 (m, 1H),6.69 (m, 1H), 3.84 (s, 3H), 3.78 (t, J=6 Hz, 2H), 3.60 (m, 2H), 3.53 (s, 3H), 1.82 (m, 2H), 1.73 (m, 2H); LC-MS (ESI+; 353 ([M+H]+)).

Provenance & Evidence