HuagongsheHuagongshe Chemistry Print Report · For research reference only
Succinic anhydride → N-{4-[(4-Methoxy-phenyl)-methyl-amino]-quinazolin-2-ylmethyl}-succinamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Succinic anhydride | HCID 7922 | — |
| Reactant | (2-Aminomethyl-quinazolin-4-yl)-(4-methoxy-phenyl)-methyl-amine | HCID 44555457 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-{4-[(4-Methoxy-phenyl)-methyl-amino]-quinazolin-2-ylmethyl}-succinamic acid | HCID 59242125 | — |
Reaction Steps
A solution of (2-aminomethyl-quinazolin-4-yl)-(4-methoxy-phenyl)-methyl-amine (76 mg, 0.25 mmol) and succinic anhydride (25 mg, 0.25 mmol) was stirred overnight in CH2Cl2 (1 mL). Solvent removal yielded the title compound. 1H NMR (CDCl3) δ 7.80-7.75 (m, 1H), 7.61 (ddd, 1H), 7.23-7.17 (m, 2H), 7.08-6.98 (m, 4H), 4.57 (s, 2H), 3.84 (s, 3H), 3.64 (s, 3H), 2.68-2.62 (m, 4H); HRMS (ES) m/z calcd for C21H23N4O4 395.1714, found 395.1737.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309562B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-c4757b38785f47628652d164cb6f2963 |
| Source note | uspto-grants-2012_11 |