Methyl iodide → HCID 59242046, compound

Participants

Reaction Steps

(2-Chloromethyl-5-fluoro-quinazolin-4-yl)-(4-ethoxy-phenyl)-methyl-amine: NaH (60 mg, 1.5 mmol) was added to a solution of (2-chloromethyl-5-fluoro-quinazolin-4-yl)-(4-ethoxy-phenyl)-amine (184 mg, 0.5 mmol) and MeI (0.10 mL) in THF (2 mL) at rt and the reaction stirred for 2 h. MeOH and EtOAc were added. The organics were washed with brine, dried (MgSO4), filtered and concentrated. Purification by MPLC (SiO2, EtOAc/hexanes, 0-100%) provided the desired compound.

Provenance & Evidence