HCID 68515721, compound → HCID 59242033, compound

HRID 1876219Notes

Reaction equation

HRID 1876219 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[N:14]=[C:13]([CH2:18][N:19]2C(=O)C4C(=CC=CC=4)C2=O)[N:12]=[C:11]3[N:30]([C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=2)[CH3:31])=[CH:4][CH:3]=1.BrC1C=C2C(=CC=1)N=C(CN1C(=O)C3C(=CC=CC=3)C1=O)N=C2N(C1C=CC(OC)=CC=1)C>>[NH2:19][CH2:18][C:13]1[N:12]=[C:11]([N:30]([C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=2)[CH3:31])[C:10]2[C:15](=[CH:16][CH:17]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[CH:9]=2)[N:14]=1

Participants

3

Reactant 2

HCID 68515721HCID 68515721, compoundHCID 68517077HCID 68517077, compound

Product 1

HCID 59242033HCID 59242033, compound

Procedure

2-{6-(4-chloro-phenyl)-4-[(4-methoxy-phenyl)-methyl-amino]-quinazoline-2-yl-methyl}-isoindole-1,3-dione: The title compound was prepared from 2-{6-bromo-4-[(4-methoxy-phenyl)-methyl-amino]-quinazolin-2-ylmethyl}-isoindole-1,3-dione similar to Example 243. LC-MS (ESI+; 501 ([M+H]+)).

Sources & evidence

ORD record
ord-0ef7f9f2d30c4d9f86d331f67bd28e89
Source dataset
uspto-grants-2012_11
Patent number
US08309562B2

Reaction notes

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