3,3-dimethylbutanohydrazide → HCID 178446200, compound

HRID 1876273Notes

Reaction equation

HRID 1876273 reaction equation
[CH2:1]([N:6]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=2)[C:9](=O)[C:7]1=[O:8])[CH2:2][CH2:3][CH2:4][CH3:5].[CH3:19][C:20]([CH3:27])([CH3:26])[CH2:21][C:22]([NH:24][NH2:25])=[O:23]>>[CH3:18][O:17][C:14]1[CH:15]=[C:16]2[C:11](/[C:9](=[N:25]/[NH:24][C:22](=[O:23])[CH2:21][C:20]([CH3:27])([CH3:26])[CH3:19])/[C:7](=[O:8])[N:6]2[CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 43467623,3-dimethylbutanohydrazideHCID 251944561-Pentyl-6-methoxy-isatin

Product 1

HCID 178446200HCID 178446200, compound

Procedure

The title compound was prepared as a yellow solid, using 1-pentyl-6-methoxy-isatin obtained in Example 39(A) and 3,3-dimethylbutanohydrazide according to the synthetic method E. NMR (CDCl3): δ 0.91 (t, 3H), 1.10 and 1.12 (s for isomers, 9H), 1.36 to 1.39 (m, 4H), 1.55 (s, 2H), 1.67-1.70 (m, 2H), 2.29 (s, 111), 2.75 (s, 1H), 3.70 (t, 2H), 3.86 and 3.87 (s for isomers, 3H), 6.42 (s, 1H), 6.60 (d, 1H), 7.51 and 7.72 (d and br s for isomers, 1H), 12.39 and 12.98 (s and br s for isomers, 1H).

Sources & evidence

ORD record
ord-5bf4ff9d1657465bbe117c5421e0a92d
Source dataset
uspto-grants-2012_11
Patent number
US08309595B2

Reaction notes

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