3-Pyridinemethanamine → HCID 68701983, compound

HRID 1876285Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:12][C@H:11]([O:13][CH3:14])[CH2:10][C@H:9]1[C:15]([OH:17])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][NH2:25])[CH:19]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:12][C@H:11]([O:13][CH3:14])[CH2:10][C@H:9]1[C:15](=[O:17])[NH:25][CH2:24][C:20]1[CH:19]=[N:18][CH:23]=[CH:22][CH:21]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 310183-Pyridinemethanamine

HCID 15222287(4R)-1-(tert-Butoxycarbonyl)-4-methoxy-L-proline

Product 1

HCID 68701983HCID 68701983, compound

Procedure

The title compound is prepared analogously as described in example 14 step B using (2S,4R)-4-Methoxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester instead of (S)-Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester and 3-picolylamine instead of 4-methoxyphenethylamine.

Sources & evidence

ORD record: ord-f5cb95cf334c42f2b9007dea6de21bc2
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08309596B2

Reaction notes

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