Dimethylformamide → HCID 68697903, compound

Participants

Reaction Steps

50% propylphosphonic anhydride solution in 650 μl of DMF is added to a solution of 200 mg of (S)-Hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester, 7.42 mg of 4-dimethylaminopyridine and 650 μl of diisopropylethylamine in CH2Cl2. After stirring at rt for 16 hours, the reaction is quenched with aq. 2N NaOH solution, eluted through a Chem Elut extraction with CH2Cl2 and solvent is evaporated before purification by preparative HPLC is carried out (Waters Sun Fire C18 column, gradient water/acetonitrile 95/5 to 0/100) to yield the title compound.

Provenance & Evidence