4-Hydroxybenzaldehyde → HCID 44136568, compound

Participants

Reaction Steps

Following the same procedure as outlined in Example 1 step b), 4-hydroxybenzaldehyde (0.73 g, 5.95 mmol) and (2-mercaptophenyl)methanol (1 g, 7.14 mmol) in dichloromethane (30 ml) were treated with hydrogen chloride gas. After workup and chromatography, as in example 1 step b), the subtitle compound was obtained (0.91 g, 63%) as a white solid. 1H NMR (300 MHz, CDCl3, ppm) δ 5.04 (d, J=15 Hz, 1H); 5.10 (d, J=15 Hz, 1H); 5.19 (s, 1H); 6.02 (s, 1H); 6.76-6.81 (m, 2H); 6.96-7.03 (m, 1H); 7.04-7.19 (m, 3H); 7.35-7.42 (m, 2H): 13C NMR (75 MHz, CDCl3, ppm) δ 70.6; 82.8; 115.7; 125.1; 126.0, 127.5; 128.4; 129.9; 130.6; 133.1; 156.4; MS calculated for C14H12O2S+H 245 observed 245.

Provenance & Evidence