Hydrochloric Acid → 5-(4H-benzo[d][1,3]dithiin-2-yl)-2-ethoxyphenol

Participants

Reaction Steps

Hydrogen chloride gas was bubbled for three minutes at 22° C. through a solution of 4-ethoxy-3-hydroxybenzaldehyde (0.50 g, 3.0 mmol) and 2-(mercaptomethyl)benzenethiol (0.52 g, 3.3 mmol) in dichloromethane (15 ml). After an additional 15 min. the reaction mixture was poured into saturated NaHCO3 (50 ml) and extracted with dichloromethane (2×75 ml). The combined organic layer was washed with brine (30 ml), dried (Na2SO4), filtered and concentrated providing a crude solid. This solid was triturated with hexane and then purified by flash chromatography using a gradient of hexanes (100%) up to hexanes (70%:30%). Concentration of the product containing fractions provided the above subtitle compound (0.65 g, 70%) as a cream colored solid. 1H NMR (300 MHz, CDCl3, ppm) δ 1.46 (t, J=7 Hz, 3H), 3.98 (s, 3H), 4.13 (q, J=7 Hz, 2H), 5.44 (s, 1H), 5.68 (br s, 1H), 6.80 (d, J=8 Hz, 1H), 6.99 (dd, J=8 Hz, J2=2 Hz, 1H), 7.13 (d, J=2 Hz, 1H), 7.15-7.35 (m, 4H); 13C NMR (75 MHz, CDCl3, ppm) δ 15.1, 34.4, 51.2, 64.9, 111.6, 114.6, 120.0, 126.2, 127.7, 128.6, 129.4, 132.2, 135.1, 135.9, 146.0, 146.2; MS calculated for C16H16O2S2-H 303 observed 303.

Provenance & Evidence