Hydrochloric Acid → HCID 72321882, compound

Participants

Reaction Conditions

Reaction Steps

4-Fluoro-2-nitroaniline (10 g, 64 mmol) was dissolved in 6N hydrochloric acid (64 ml, 0.27 mol), sodium nitrate (4.4 g, 64 mmol) dissolved in water (50 ml) was slowly added in drops thereto at 0° C., and the mixture was stirred for 30 min at 0° C.˜room temperature. Simultaneously, ethyl 2-methylacetoacetate (9.2 ml, 64 mmol) and sodium hydroxide (19 g, 0.34 mol) were dissolved in 80% aqueous ethanol solution (95 ml), and stirred for 10 min at 0° C. The two solutions thus prepared were mixed, and stirred for 8 h at 0° C.˜room temperature. Water was added to the reaction solution, and the insoluble solid was collected. The solid was washed with water, and dried to give the title compound (7.9 g, Yield 46%).

Provenance & Evidence