Triethylamine → HCID 86646767, compound

Participants

Reaction Conditions

Reaction Steps

The compound (820 mg, 2.6 mmol) prepared in Example 1 was dissolved in dichloromethane (50 ml). Methanesulfonyl chloride (0.24 ml, 3.1 mmol) and triethylamine (0.81 ml, 3.1 mmol) were added thereto, and the mixture was stirred for 30 min at 0° C. After completion of the reaction, saturated sodium bicarbonate solution was added, and the mixture was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, and filtered. The filtrate was distilled under reduced pressure, and purified by column chromatography to give the title compound (600 mg, Yield 60%).

Provenance & Evidence