Dimethylamine → HCID 59543070, compound

HRID 1876320Notes

Reaction equation

HRID 1876320 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][C:23](O)=[O:24])[N:21]=1)=[CH:5]2.[CH3:26][NH:27][CH3:28]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:13][CH2:14][CH2:15][CH2:16]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][C:23]([N:27]([CH3:28])[CH3:26])=[O:24])[N:21]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 674DimethylamineHCID 25196145[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]acetic acid

Product 1

HCID 59543070HCID 59543070, compoundYield 49%

Procedure

The compound (50 mg, 0.13 mmol) prepared in Example 27 and dimethylamine instead of morpholine were reacted according to the same procedure as Example 73 to give the title compound (26 mg, Yield 49%).

Sources & evidence

ORD record
ord-05205017cb974aea9dc0eb250905c59a
Source dataset
uspto-grants-2012_11
Patent number
US08309586B2

Reaction notes

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