Morpholine → HCID 59542971, compound

HRID 1876326Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:18]1[S:19][CH2:20][C@@H:21]([CH2:23][C:24]([OH:26])=O)[N:22]=1)=[CH:5]2.[NH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:18]1[S:19][CH2:20][C@@H:21]([CH2:23][C:24]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[O:26])[N:22]=1)=[CH:5]2

Participants

Reactant 2

HCID 8083Morpholine

HCID 25196936HCID 25196936, compound

Product 1

HCID 59542971HCID 59542971, compoundYield 68%

Procedure

The compound (44 mg, 0.11 mmol) prepared in Example 31 and morpholine instead of methylamine were reacted according to the same procedure as Example 82 to give the title compound (35 mg, Yield 68%).

Sources & evidence

ORD record: ord-e1a904ebc9074ab5978127f99774dd98
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08309586B2

Reaction notes

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