1-Acetylpiperazine → HCID 59543116, compound

HRID 1876329Notes

Reaction equation

[CH:1]1([NH:6][C:7]2[CH:8]=[C:9]([F:25])[CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[S:17][CH2:18][C@@H:19]([CH2:21][C:22](O)=[O:23])[N:20]=2)=[CH:12]3)[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:26]([N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1)(=[O:28])[CH3:27]>>[C:26]([N:29]1[CH2:34][CH2:33][N:32]([C:22](=[O:23])[CH2:21][C@@H:19]2[CH2:18][S:17][C:16]([C:13]3[NH:14][C:15]4[C:11]([CH:12]=3)=[CH:10][C:9]([F:25])=[CH:8][C:7]=4[NH:6][CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5]3)=[N:20]2)[CH2:31][CH2:30]1)(=[O:28])[CH3:27]

Participants

Reactant 2

HCID 837951-Acetylpiperazine

HCID 59543018HCID 59543018, compound

Product 1

HCID 59543116HCID 59543116, compoundYield 55%

Procedure

The compound (100 mg, 0.28 mmol) prepared in Example 37 and 1-acetylpiperazine instead of 1-methylpiperazine were reacted according to the same procedure as Example 84 to give the title compound (60 mg, Yield 55%).

Sources & evidence

ORD record: ord-bc292b24db524015bb00332b77a76249
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08309586B2

Reaction notes

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