Morpholine → HCID 59543108, compound

HRID 1876331Notes

Reaction equation

HRID 1876331 reaction equation
[CH:1]1([NH:6][C:7]2[CH:8]=[C:9]([O:25][CH3:26])[CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[S:17][CH2:18][C@@H:19]([CH2:21][C:22](O)=[O:23])[N:20]=2)=[CH:12]3)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[CH:1]1([NH:6][C:7]2[CH:8]=[C:9]([O:25][CH3:26])[CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[S:17][CH2:18][C@@H:19]([CH2:21][C:22]([N:27]4[CH2:32][CH2:31][O:30][CH2:29][CH2:28]4)=[O:23])[N:20]=2)=[CH:12]3)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 25197164HCID 25197164, compound

Product 1

HCID 59543108HCID 59543108, compoundYield 24%

Procedure

The compound (83 mg, 0.22 mmol) prepared in Example 48 and morpholine instead of methylamine were reacted according to the same procedure as Example 87 to give the title compound (24 mg, Yield 24%).

Sources & evidence

ORD record
ord-c5976b1a34054f93a35a95fe2a3ce4ab
Source dataset
uspto-grants-2012_11
Patent number
US08309586B2

Reaction notes

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