HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 2-[(R)-2-(7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-N-methyl-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | [(R)-2-(7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]acetic acid | HCID 25197052 | — |
| Product | 2-[(R)-2-(7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-N-methyl-acetamide | HCID 59543104 | 34% |
Reaction Steps
The compound (97 mg, 0.28 mmol) prepared in Example 42 and methylamine instead of ethylamine were reacted according to the same procedure as Example 89 to give the title compound (34 mg, Yield 34%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309586B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-924bf41e8cd844e29e900af2809974e3 |
| Source note | uspto-grants-2012_11 |