Imidazole → HCID 59543005, compound

Participants

Reaction Steps

The compound (3.7 g, 10.2 mmol) prepared in Example 32 was dissolved in tetrahydrofuran (100 ml). Imidazole (2.1 g, 30.6 mmol), triphenylphosphine (4.0 g, 15.3 mmol), and iodine (3.9 g, 15.3 mmol) were added thereto, and the mixture was stirred for 8 h at 0° C.˜room temperature. After completion of the reaction, ethyl acetate (100 ml) was added, and the mixture was washed with water (2×100 ml). The organic layer was concentrated, and the residue was separated by column chromatography to give the title compound (2.0 g, 4.07 mmol, Yield 40%).

Provenance & Evidence