Water → HCID 59542961, compound

Participants

Reaction Steps

The compound (85 mg, 0.19 mmol) prepared in Example 115 was dissolved in dichloromethane (10 ml). Diisopropylethylamine (0.13 ml, 0.75 mmol) and acetyl chloride (0.013 ml, 0.19 mmol) were added thereto, and the mixture was stirred for 30 min at room temperature. After completion of the reaction, water was added. The mixture was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, and filtered. The filtrate was distilled under reduced pressure, and concentrated. The residue was purified by column chromatography to give the title compound (39 mg, Yield 42%).

Provenance & Evidence