1-Tetrazolylacetic acid → HCID 59542973, compound

HRID 1876342Notes

Reaction equation

HRID 1876342 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:18]1[S:19][CH2:20][C@@H:21]([CH2:23][CH2:24][N:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)[N:22]=1)=[CH:5]2.[N:31]1([CH2:36][C:37](O)=[O:38])[CH:35]=[N:34][N:33]=[N:32]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:18]1[S:19][CH2:20][C@@H:21]([CH2:23][CH2:24][N:25]3[CH2:30][CH2:29][N:28]([C:37](=[O:38])[CH2:36][N:31]4[CH:35]=[N:34][N:33]=[N:32]4)[CH2:27][CH2:26]3)[N:22]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 5432071-Tetrazolylacetic acidHCID 59543060HCID 59543060, compound

Product 1

HCID 59542973HCID 59542973, compoundYield 48%

Procedure

The compound (61 mg, 0.14 mmol) prepared in Example 117 and 1H-tetrazole-1-acetic acid instead of glycolic acid were reacted according to the same procedure as Example 118 to give the title compound (31 mg, Yield 48%).

Sources & evidence

ORD record
ord-fc323b1a33b44ab783d3fddea9cc8b5a
Source dataset
uspto-grants-2012_11
Patent number
US08309586B2

Reaction notes

Loading…