HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrobenzaldehyde → Ethyl (E)-2-methyl-3-(4-nitrophenyl)prop-2-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrobenzaldehyde | HCID 541 | — |
| Reactant | Ethyl 2-(triphenylphosphoranylidene)propionate | HCID 79792 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl (E)-2-methyl-3-(4-nitrophenyl)prop-2-enoate | HCID 11241815 | — |
Reaction Steps
A solution of 4-nitrobenzaldehyde (2 g, 13.2 mmol) and (1-ethoxy carbonylethylidene)triphenyl phosphorane (4.80 g, 13.2 mmol) in tetrahydrofuran (130 mL) was refluxed for 24 hours. The reaction was concentrated in vacuo and was purified by flash column chromatography on silica gel with hexanes and EtOAc to give (E)-ethyl 2-methyl-3-(4-nitrophenyl)acrylate (645).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309600B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-477abf0fce6a4070a0ba3105fe1404e6 |
| Source note | uspto-grants-2012_11 |