HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → (E)-ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)acrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Carboxymethylene triphenylphosphorane | HCID 10870911 | — |
| Reactant | 5-Hydroxy-[1,1'-biphenyl]-2-carbaldehyde | HCID 57303464 | — |
| Product | (E)-ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)acrylate | HCID 58566652 | — |
Reaction Steps
A solution of 5-hydroxy-[1,1′-biphenyl]-2-carbaldehyde (651) (292 mg, 1.47 mmol) and (carboxymethylene)-triphenylphosphorane (564.5 mg, 1.62 mmol) in toluene (15 mL) was refluxed for 24 hours. The reaction was concentrated in vacuo and was purified by flash column chromatography on silica gel with hexanes and EtOAc (30%) to give (E)-ethyl 3-(5-hydroxy-[1,1′-biphenyl]-2-yl)acrylate (652).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309600B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-21d7c15680e44dcbb9e9f0fccf7fda5d |
| Source note | uspto-grants-2012_11 |