HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-chloro-7-(chloromethyl)-2,2-dimethylbenzofuran-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-chloro-7-(hydroxymethyl)-2,2-dimethylbenzofuran-3(2H)-one | HCID 58566578 | — |
| Product | 5-chloro-7-(chloromethyl)-2,2-dimethylbenzofuran-3(2H)-one | HCID 58566724 | — |
Reaction Steps
A solution of 5-chloro-7-(hydroxymethyl)-2,2-dimethylbenzofuran-3(2H)-one (656) (278 mg, 1.23 mmol) in neat thionyl chloride (5 mL) was stirred at room temperature for 48 hours. The reaction was concentrated to obtain 5-chloro-7-(chloromethyl)-2,2-dimethylbenzofuran-3(2H)-one (657) as a brown/grey solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309600B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-86d61e08ccd84ebfa08afd3addf53597 |
| Source note | uspto-grants-2012_11 |