(E)-ethyl 3-(4-(benzyloxy)-2-isopropoxyphenyl)acrylate → Ethyl 3-(4-hydroxy-2 isopropoxyphenyl)propanoate

Participants

Reaction Steps

To (E)-ethyl 3-(4-(benzyloxy)-2-isopropoxyphenyl)acrylate (699) (530 mg, 1.56 mmol) in ethanol (12 mL) was added Pd/C (0.5 eq, 10% Degussa type). A balloon of hydrogen gas was added and the reaction was evacuated and back-filled with hydrogen three times. The reaction was stirred overnight at room temperature, filtered through a pad of celite and concentrated in vacuo to give ethyl 3-(4-hydroxy-2 isopropoxyphenyl)propanoate (700).

Provenance & Evidence