反应详情

5% Palladium carbon (3.6 g) was added to an ethanol (700 ml) solution of the compound (35.5 g, 86.5 mmol) obtained in Step 1 above and contact reduction was performed for 2 hours in a hydrogen atmosphere. The catalyst was filtrated through celite, the filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to give the title compound (20 g, 100%) as a colorless solid.

1. filtrationThe catalyst was filtrated through celite
2. concentrationthe filtrate was concentrated under reduced pressure
3. customthe resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1)