Sodium Bicarbonate → HCID 59465931, Verbindung

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Sodium Bicarbonate	HCID 516892	—
Edukt	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Edukt	1,2,4-Thiadiazol-5-amine--hydrogen chloride (1/1)	HCID 22014543	—
Edukt	(r)-4-(3-Methylpiperazin-1-yl)-n-(1,2,4-thiadiazol-5-yl)benzenesulfonamide	HCID 59465674	—
Edukt	7-Chloro-indole-1-acetic acid	HCID 67082699	—
Produkt	HCID 59465931	HCID 59465931	288,7%

Reaktionsschritte

Synthesized according to general procedure 9, method B. The reaction was set up with (R)-4-(3-methylpiperazin-1-yl)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (400 mg, 1.2 mmol), 2-(7-chloro-1H-indol-1-yl)acetic acid (250 mg, 0.15 mmol), HATU reagent (390 mg, 0.15 mmol), sodium bicarbonate (151 mg, 1.8 mmol), and DMF/CH2Cl2-1/1 (1.0 mL) to obtain the desired amide as a white solid (230 mg, 36% yield). LC/MS (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)), m/z: M+1 obs=531.0; tR=3.21 min.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08309587B2
Quelldatensatz	uspto-grants-2012_11
ORD ID	ord-d6c2a45518964d32b9fde70d9d2a47fb
Quellennotiz	uspto-grants-2012_11