HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 2,2,2-trifluoro-N-(2-methyl-4-(N-thiazol-2-ylsulfamoyl)phenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 3-Methyl-4-(2,2,2-trifluoroacetamido)benzene-1-sulfonyl chloride | HCID 53627670 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2,2,2-trifluoro-N-(2-methyl-4-(N-thiazol-2-ylsulfamoyl)phenyl)acetamide | HCID 59465670 | 76% |
Reaction Steps
Synthesized according to general procedure 70. Under an N2 atmosphere, a mixture of 3-methyl-4-(2,2,2-trifluoroacetamido)benzene-1-sulfonyl chloride (7.5 g, 24.9 mmol) and 2-aminothiazole (2.49 g, 24.9 mmol), and pyridine (15 mL) was stirred at RT for 19 h. Purification via silica gel chromatography using 0-10% MeOH in CH2Cl2 gave 2,2,2-trifluoro-N-(2-methyl-4-(N-thiazol-2-ylsulfamoyl)phenyl)acetamide (6.87 g, 76%). LC/MS (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)), m/z: M+1 obs=366.1; tR=1.13 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309587B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-e4f303eec95c4843bbcc08c7e88e4be3 |
| Source note | uspto-grants-2012_11 |