HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 131730057, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one | HCID 11306691 | — |
| Reactant | HCID 15697366 | HCID 15697366 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 131730057 | HCID 131730057 | 66.3% |
Reaction Steps
A mixture of methanol (390 mL), water (80 mL), 7-(1-oxo-3-amino-4-(2,4,5-trifluorophenyl)-butyl)-3-trifluoromethyl-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine (13 g), and di-p-tolyl-L-tartaric acid (13 g) is stirred for about 24 hours. The separated solid is filtered off, washed with ethanol (15 mL) and dried at about 45° C. to afford the title compound. (Yield: 66.3%; purity by HPLC: 99.93%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309724B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-93ab6a40b00047b2a537329ec4d94a93 |
| Source note | uspto-grants-2012_11 |