p-Toluenesulfonic acid → HCID 69032472, compound

Participants

Reaction Steps

A mixture of 3-(4-(2-chloropyrimidin-4-yl)-1H-pyrazol-1-yl)-4-(1-(2,4-difluorobenzoyl)piperidin-4-yl)butanenitrile (30 mg, 0.06 mmol), 4-(1H-imidazol-1-yl)aniline (15.2 mg, 0.0956 mmol), and p-toluenesulfonic acid (9.3 mg, 0.054 mmol) in dry 1,4-dioxane (0.5 mL) was refluxed overnight. The mixture was diluted with acetonitrile and water, purified on RP-HPLC to give the desired product as a racemic mixture (25 mg, 71%). LCMS (M+H) 594.1.

Provenance & Evidence