Water → HCID 58014541, compound

Participants

Reaction Steps

A mixture of 3-(4-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)pyrimidin-2-ylamino)benzoic acid (228 mg, 0.566 mmol), and diphenylphosphonic azide (0.18 mL, 0.85 mmol), triethylamine (0.16 mL, 1.1 mmol) in 1,4-dioxane (4.2 mL) was stirred at room temperature overnight. To the resulting mixture was added water (0.36 mL). The reaction was refluxed overnight. The crude racemic mixture was used directly in next step. An analytically pure sample was obtained by RP-HPLC (pH 2). LCMS (M+H) 374.1.

Provenance & Evidence