HCID 68733241, compound → HCID 68731995, compound

HRID 1876879Notes

Reaction equation

HRID 1876879 reaction equation
[CH3:1][C:2]1([CH3:22])[C:6]2([CH2:10][CH2:9][N:8](C(OCC3C=CC=CC=3)=O)[CH2:7]2)[O:5][C:4](=[O:21])[NH:3]1.[H][H]>CO.[Pd]>[CH3:1][C:2]1([CH3:22])[C:6]2([CH2:10][CH2:9][NH:8][CH2:7]2)[O:5][C:4](=[O:21])[NH:3]1

Participants

5

Reactant 2

HCID 68733241HCID 68733241, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68731995HCID 68731995, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of benzyl 4,4-dimethyl-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-7-carboxylate (0.50 g, 0.0016 mol) (2nd peak from chiral separation) in 20 mL of MeOH was hydrogenated in the presence of 10% Pd/C, under a balloon pressure of hydrogen, for 2 h. After filtering off the catalyst, the filtrate was concentrated to dryness and the resultant residue was used directly in next step. LCMS (M+H) 171.2.

Workup

  1. filtrationAfter filtering off the catalyst
  2. concentrationthe filtrate was concentrated to dryness

Sources & evidence

ORD record
ord-5dc88414ba96494a830283828b89abf4
Source dataset
uspto-grants-2012_11
Patent number
US08309718B2

Reaction notes

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