1-(2-(4-Nitrophenoxy)ethyl)pyrrolidine → HCID 58014433, compound

HRID 1876889Notes

Reaction equation

HRID 1876889 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[N:10][N:11]([C:13]3([CH2:19][C:20]#[N:21])[CH2:16][CH:15]([C:17]#[N:18])[CH2:14]3)[CH:12]=2)[CH:5]=[CH:4][N:3]=1.[N+:22]([C:25]1[CH:38]=[CH:37][C:28]([O:29][CH2:30][CH2:31][N:32]2[CH2:36][CH2:35][CH2:34][CH2:33]2)=[CH:27][CH:26]=1)([O-])=O>>[C:20]([CH2:19][C:13]1([N:11]2[CH:12]=[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([NH:22][C:25]4[CH:38]=[CH:37][C:28]([O:29][CH2:30][CH2:31][N:32]5[CH2:36][CH2:35][CH2:34][CH2:33]5)=[CH:27][CH:26]=4)[N:7]=3)[CH:9]=[N:10]2)[CH2:16][CH:15]([C:17]#[N:18])[CH2:14]1)#[N:21]

Participants

3

Reactant 2

HCID 4198581-(2-(4-Nitrophenoxy)ethyl)pyrrolidineHCID 86637301HCID 86637301, compound

Product 1

HCID 58014433HCID 58014433, compound

Procedure

The cis- and trans-isomers of the titled compound were prepared as a racemic mixture according to the procedure described in example 306, using 3-(4-(2-chloropyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)-cyclobutanecarbonitrile and 1-[2-(4-nitrophenoxy)ethyl]pyrrolidine as starting materials. First isomer retention time 1.055 min, LCMS (M+H) 469.4. Second peak retention time 1.072 min, LCMS (M+H) 469.4.

Sources & evidence

ORD record
ord-7c92cfdec8664a7e91bea10ef4e12e88
Source dataset
uspto-grants-2012_11
Patent number
US08309718B2

Reaction notes

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