p-Toluenesulfonic acid → HCID 58014460, compound

Participants

Reaction Steps

A mixture of 3-[4-(2-chloropyrimidin-4-yl)-1H-pyrazol-1-yl]-3-(tetrahydro-2H-pyran-4-yl)propanenitrile (20 mg, 0.00008 mol), 4-morpholin-4-ylaniline (20.1 mg, 0.000113 mol), and p-toluenesulfonic acid (11 mg, 0.000064 mol) in dry 1,4-dioxane (0.5 mL, 0.006 mol) was refluxed overnight. The mixture was diluted with acetonitrile and water, purified on RP-HPLC at pH 10 to provide the desired product as a racemic mixture (free base). LCMS (M+H) 460.4.

Provenance & Evidence