4-Aminobenzoic Acid → HCID 68754988, compound

Participants

Reaction Steps

A mixture of 3-[4-(2-chloropyrimidin-4-yl)-1H-pyrazol-1-yl]-3-(tetrahydro-2H-pyran-4-yl)propanenitrile (from example 308 step 3, 140 mg, 0.00044 mol), p-aminobenzoic acid (90.6 mg, 0.000661 mol), and p-toluenesulfonic acid (64 mg, 0.00037 mol) in dry 1,4-dioxane (3 mL, 0.04 mol) was refluxed overnight, cooled to room temperature. The desired product crashed out and was collected by filtration (180 mg, 97.64%). LCMS (M+H) 419.3.

Provenance & Evidence