Dimethylformamide → HCID 58014468, compound

Participants

Reaction Steps

To a mixture of 4-[(4-{1-[2-cyano-1-(tetrahydro-2H-pyran-4-yl)ethyl]-1H-pyrazol-4-yl}pyrimidin-2-yl)amino]benzoic acid (20 mg, 0.00005 mol), tetrahydro-2H-pyran-4-amine (4.8 mg, 0.000048 mol) and benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (25 mg, 0.000057 mol) in N,N-dimethylformamide (0.3 mL, 0.004 mol) was added N,N-diisopropylethylamine (20 μL, 0.00011 mol). The reaction was stirred at room temperature for 1 h, quenched with water, purified on HPLC to obtain the desired product as a racemic mixture (free base). LCMS (M+H) 502.4.

Provenance & Evidence