反应详情

To a stirred solution of 4-(4-fluorophenyl)-1H-imidazole (10 g, 62 mmol) in 95% ethanol (25 mL) was added aqueous formaldehyde solution (37%, 9 mL) slowly. The reaction mixture was stirred at RT for 1 hr before water (25 mL) was added. The reaction mixture was stirred at RT for an additional 3 hr. The solid that separated from solution out was filtered, washed with aqueous ethanol solution, and dried to give (4-(4-fluorophenyl)-1H-imidazol-1-yl)methanol (11.4 g, 59 mmol, 96% yield) as a solid. MS found: (M+H—CH2O)+=163.1.

1. additionwas added
2. customThe solid that separated from solution
3. filtrationout was filtered
4. washwashed with aqueous ethanol solution
5. customdried