Formaldehyde → HCID 67447090, compound

HRID 1876910Notes

Reaction equation

HRID 1876910 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:4][CH:3]=1.[CH2:13]=[O:14].O>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[CH:10][N:11]([CH2:13][OH:14])[CH:12]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 962WaterHCID 178418867HCID 178418867, compound

Product 1

HCID 67447090HCID 67447090, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of 4-(4-fluorophenyl)-1H-imidazole (10 g, 62 mmol) in 95% ethanol (25 mL) was added aqueous formaldehyde solution (37%, 9 mL) slowly. The reaction mixture was stirred at RT for 1 hr before water (25 mL) was added. The reaction mixture was stirred at RT for an additional 3 hr. The solid that separated from solution out was filtered, washed with aqueous ethanol solution, and dried to give (4-(4-fluorophenyl)-1H-imidazol-1-yl)methanol (11.4 g, 59 mmol, 96% yield) as a solid. MS found: (M+H—CH2O)+=163.1.

Workup

  1. additionwas added
  2. customThe solid that separated from solution
  3. filtrationout was filtered
  4. washwashed with aqueous ethanol solution
  5. customdried

Sources & evidence

ORD record
ord-25d8ff87372e4f7fbd580a5300540103
Source dataset
uspto-grants-2012_11
Patent number
US08309730B2

Reaction notes

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